hemophilia

posted on 25 Apr 2013 22:12 by ononmedicine
hemophilia
เป็นโรคเลือดออกง่ายแต่หยุดยาก เป็นโรคทางพันธุกรรม
เกิดจากการขาดปัจจัยในการแข็งตัวของเลือด
 แบ่งออกเป็น 3 ชนิด คือ
1.hemophilia A เกิดจากการขาด factor 8 
ถ่ายทอดแบบ X-link recessive
2.hemophilia B เกิดจากการขาด factor 9 
ถ่ายทอดแบบ X-linkrecessive
3.Hemophilia C เกิดจากการขาด factor 11
ถ่ายทอดแบบ autosomal recessive
 
อาการจะมีเลือดออกง่ายและหยุดยาก ในทารกแรกเกิดที่คลอด โดยใช้เครื่องดูดหรือใช้คีม จะมีเลือดออกใต้ผิวหนังที่ศีรษะ หรืออาจพบเลือดออกมากจากการขลิบหนังหุ้มปลายอวัยวะเพศ พบจ้ำเขียว (Ecchymosis) ตามลำตัว แขนขา อาจจะพบเป็นจ้ำใหญ่หรือก้อนนูน ภายหลังการฉีดยาเข้ากล้ามเนื้อ อาจพบเลือดออกมากภายหลังฟันหลุด ถอนฟัน ได้รับอุบัติเหตุ ตำแหน่งที่พบเลือดออกได้บ่อยและเป็นลักษณะเฉพาะของโรค ก็คือเลือดออกในข้อ (Hemathrosis) ข้อที่พบบ่อยคือข้อเข่า ข้อเท้า ข้อศอก และข้อนิ้วเท้าตามลำดับ ทำให้ข้อบวม เจ็บปวด เคลื่อนไหวได้จำกัด กล้ามเนื้อจะลีบเล็กลงจากการไม่ได้ใช้งาน ข้อจะบวมใหญ่จากมีของเหลวคั่งอยู่ เกิดการติดแข็งของข้อ เกิดความพิการของข้อในท่างอตามมา
 
http://www.hemophiliathai.com/2011/12/what-is-hemophilia.html

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